STEPWISE INTRODUCTION OF TRANSFORMABLE PENICILLIN RESISTANCE IN PNEUMOCOCCUS
نویسندگان
چکیده
منابع مشابه
Stepwise introduction of transformable penicillin resistance in Pneumococcus.
ITH the introduction of drug resistances into Pneumococcus by DNA transWf ormation (HOTCHKISS 1951), it became clear that heritable traits not presumably connected to the classic capsular antigens (AVERY, MACLEOD and MCCARTY 1944; AUSTRIAN and MACLEOD 1949) could also be carried by DNA. Certain practical and conceptual developments were derived from this finding. Selective resistance markers al...
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Introduction of 13-valent pneumococcal conjugate vaccine in the United States was not associated with a significant change in prevalence of penicillin resistance in nonvaccine type serotypes because of the variable success of highly resistant serotypes. Differences in regional serotype distribution and serotype-specific resistance contributed to geographic heterogeneity of penicillin resistance.
متن کاملPenicillin resistant pneumococcus.
Resistance to other antimicrobial agents and chloramphenicol has also been reported. 4,5 Multiple resistant strains have been responsible for infection with a high mortality rate. 5 To our knowledge, isolation of penicillin resistant pneumococci has not been documented in this region. We report the isolation of a penicillin resistant strain from the throat of an eleven-month old baby boy and th...
متن کاملPenicillin-resistant pneumococcus and risk of treatment failure in pneumonia.
OBJECTIVE To determine whether the presence of in vitro penicillin-resistant Streptococcus pneumoniae increases the risk of clinical failure in children hospitalised with severe pneumonia and treated with penicillin/ampicillin. DESIGN Multicentre, prospective, observational study. SETTING 12 tertiary-care centres in three countries in Latin America. PATIENTS 240 children aged 3-59 months,...
متن کاملPermeability and penicillin-binding protein alterations in Salmonella muenchen: stepwise resistance acquired during beta-lactam therapy.
A patient with Salmonella muenchen sepsis was unsuccessfully treated with ampicillin. During therapy, four strains that showed stepwise ampicillin resistance and affected other beta-lactams and unrelated antibiotics were isolated sequentially. Resistance was caused by decreased outer membrane permeability associated with diminished expression of porin OmpF. Furthermore, the most resistant isola...
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ژورنال
عنوان ژورنال: Genetics
سال: 1970
ISSN: 1943-2631
DOI: 10.1093/genetics/64.3-4.397